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- During prophase, the key events include
- chromosome condensation, centriole migration,
- spindle formation, and the breakdown and
- disappearance of the nuclear membrane and of
- the nucleoli. By late prophase, each individual
- chromosome's twin chromatids become visible,
- appearing as short rod-like structures.
- Kinetochore microtubules, which will
- eventually attach the chromosomes to the spindle,
- begin to radiate from each chromosome's
- centromere. The disintegration of the nuclear
- membrane allows the spindle's fibers to enter
- the nucleus. During metaphase, the kinetochore
- fibers radiating from each centromere become
- linked to two polar microtubules, one from each
- pole of the cell. As a consequence of this
- interconnection, the chromosomes become aligned
- near the equatorial plane of the cell.
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